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Ultrasound based Control of Micro Bubbles for Exosome Delivery in Treating COVID 19 Lung Damage

Posted: 21-06-2021

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Walton Institute’s Caio Fonseca recently presented at this year’s IEEE International Conference on Communications (ICC). The ICC is one of the IEEE Communications Society’s two flagship conferences dedicated to driving innovation in communication. The Theme of the ICC 2021 Conference was “CONNECTIVITY – SECURITY – PRIVACY”.

Fonseca’s presentation focused on the paper “Ultrasound based Control of Micro Bubbles for Exosome Delivery in Treating COVID 19 Lung Damage” written by Bruna Fonseca, Caio Fonseca, Michael Barros, Mark White, Vinay Abhyankar, David A Borkholder and Sasitharan Balasubramaniam.

IEEE International Conference on Communications Presentation by Caio Fonseca,
Walton Institute June 2021

The recent COVID-19 pandemic has resulted in high fatality rates, especially for patients who suffer from underlying health issues. One of the more serious symptoms exhibited from patients suffering from an acute COVID-19 infection is breathing difficulties and shortness of breath, which is largely due to the excessive fluid (cellular leakage and cytokine storm) and mucoid debris that have filled lung alveoli and reduced the surfactant tension resulting in heavy and stiff lungs.

This paper proposes the use of micro-bubbles filled with exosomes that can be released upon exposure to ultrasound signals as a possible rescue therapy in deteriorating COVID-19 patients. Recent studies have shown that exosomes can be used to repair and treat lung damage for patients who have suffered from the viral infection. The research team conducted simulations to show the efficacy of the ultrasound signals that will penetrate through layers of tissues reaching the alveoli that contains the micro-bubbles.

Results have shown that ultrasound signals with low frequencies are required to oscillate and rupture the polymer-based micro-bubbles. This proposed system can be used for patients who require immediate rescue treatments for lung damage, as well as for recovered patients who may suffer from viral relapse infection, where the micro-bubbles will remain dormant for a temporary therapeutic window until they are exposed to the ultrasound signals.